Major ECG abnormalities in healthy middle-aged subjects were associated with an increased risk of cardiac death at 10 years (HR 1.7; 95% CI 1.1-2.5; p=0.009) and 30 years.
Cohort (n=9,511)
Do major ECG abnormalities predict fatal and non-fatal cardiac events in asymptomatic middle-aged subjects without known cardiac disease?
Major ECG abnormalities in asymptomatic middle-aged subjects predict long-term cardiac mortality but offer minimal improvement in risk discrimination models.
Effect estimate: HR 1.7 (95% CI 1.1-2.5)
p-value: p=0.009
INTRODUCTION: The long-term prognostic value of a standard 12-lead electrocardiogram (ECG) for predicting cardiac events in apparently healthy middle-aged subjects is not well defined. MATERIALS AND METHODS: A total of 9511 middle-aged subjects (mean age 43 ± 8.2 years, 52% males) without a known cardiac disease and with a follow-up 40 years were included in the study. Fatal and non-fatal cardiac events were collected from the national registries. The predictive value of ECG was separately analyzed for 10 and 30 years. Major ECG abnormalities were classified according to the Minnesota code. RESULTS: Subjects with major ECG abnormalities (N = 1131) had an increased risk of cardiac death after 10-years (adjusted hazard ratio HR 1.7; 95% confidence interval 95% CI, 1.1-2.5, p = 0.009) and 30-years of follow-up (HR 1.3, 95% CI, 1.1-1.5, p < 0.001). Model discrimination measured with the C-index showed only a minor improvement with the inclusion of ECG abnormalities: 0.851 versus 0.853 and 0.742 versus 0.743 for 10- and 30-year follow-up, respectively. ECG did not predict non-fatal cardiac events after 10-years or 30-years of follow-up. DISCUSSION: Major ECG abnormalities are associated with an increased risk of short and long-term cardiac mortality in middle-aged subjects. However, the improvement in discrimination between subjects with and without fatal cardiac events was marginal with abnormal ECG. KEY MESSAGES: Abnormalities observed on 12-lead electrocardiogram are shown to have prognostic significance for cardiac events in elderly subjects without known cardiac disease. Our results suggest that ECG abnormalities increase the risk of fatal cardiac events also in middle-aged healthy subjects.
Terho et al. (Thu,) conducted a cohort in Asymptomatic without known cardiac disease (n=9,511). Major ECG abnormalities vs. No major ECG abnormalities was evaluated on Cardiac death after 10-years (HR 1.7, 95% CI 1.1-2.5, p=0.009). Major ECG abnormalities in healthy middle-aged subjects were associated with an increased risk of cardiac death at 10 years (HR 1.7; 95% CI 1.1-2.5; p=0.009) and 30 years.
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