January 1, 1979Annals of Internal Medicine
Anticoagulants and Myocardial Infarction
Key result
Anticoagulation benefits in acute myocardial infarction derived from a recent pooled analysis are disputed due to unfulfilled scientific, statistical, and clinical standards.
Design
Editorial
Authors
Discussion
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Member takes
Implication
Methodological critique of pooling old retrospective data to evaluate anticoagulation in acute myocardial infarction.
Key Points
- This analysis questions the validity of using pooled data to establish the benefits of anticoagulants in myocardial infarction.
- Combined retrospective data from multiple studies on anticoagulants in myocardial infarction.
- Analyzed scientific and statistical validity of the pooled data approach.
- Pooled data suggested anticoagulation improves outcomes in myocardial infarction.
- Concerns raised about the validity due to differences in patient factors and treatment across studies.
PICO
P
Population
acute myocardial infarction
I
Intervention / Comparator
Anticoagulants
Methodological critique of pooling old retrospective data to evaluate anticoagulation in acute myocardial infarction.
Limitations
- Pooling data from different sources may be invalid if component studies lack similarity in patient characteristics and treatments
- Recent changes in ancillary therapy may negate the applicability of old data
Cite This Study
Goldman et al. (1979) conducted an editorial in acute myocardial infarction. Anticoagulants was evaluated. Anticoagulation benefits in acute myocardial infarction derived from a recent pooled analysis are disputed due to unfulfilled scientific, statistical, and clinical standards.