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Although the C-based interpreter of Python is reasonably fast, implementations on the CLI or the JVM platforms offers some advantages in terms of robustness and interoperability. Unfortunately, because the CLI and JVM are primarily designed to execute statically typed, object-oriented languages, most dynamic language implementations cannot use the native bytecodes for common operations like method calls and exception handling; as a result, they are not able to take full advantage of the power offered by the CLI and JVM.
Ancona et al. (Mon,) studied this question.