March 4, 2020Circulation JournalOpen Access

Validation of Intraoperative Catheter Phase Mapping Using a Simultaneous Optical Measurement System in Rabbit Ventricular Myocardium

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Why the study?

The mapping accuracy of the ExTRa Mapping (EXT) intraoperative catheter electrode mapping system remained unclear.

Does ExTRa Mapping (EXT) accurately identify activation patterns compared to optical mapping in excised rabbit hearts with induced ventricular tachyarrhythmia?

Population

Excised rabbit hearts (n=8, 42 episodes) with induced spiral wave re-entries

Comparison

EXT phase mapping vs high-resolution optical membrane potential mapping

Design

Ex vivo validation study

Authors

NTNaoki TomiiThe University of Tokyo KAKeisuke AsanoThe University of Tokyo HSHiroshi SenoKyoto University

Discussion

Member takes

Implication

Should not yet change clinical mapping; leaves open EXT translation to human arrhythmias.

Structured PICO

Does ExTRa Mapping (EXT) accurately identify activation patterns compared to optical mapping in excised rabbit hearts with induced ventricular tachyarrhythmia?

Population

Excised rabbit hearts (n=8, 42 episodes analyzed) from Japanese white rabbits (weight 1.7-2.0 kg) of both sexes, with induced ventricular tachyarrhythmia (spiral wave re-entries and 1-way propagation).

Intervention

ExTRa Mapping (EXT) phase map sequence estimation using a transparent silicone electrode plate (70% scale of clinical catheter).

Comparator

High-resolution optical membrane potential mapping (OPT) using di-4-ANEPPS voltage-sensitive dye.

Outcome

Accuracy of activation pattern identification (one-directed propagations vs rotational activities) and correlation of the non-passive period ratio (%NP).surrogate

ExTRa Mapping accurately identifies complex activation patterns and spiral wave re-entries in an ex vivo rabbit model, supporting its reliability for analyzing electrode signals during arrhythmias.

Limitations

Differences between animal experiments and clinical measurements
Measured rabbit ventricular epicardial surface instead of human atrial endocardial surface
Electrode arrangement was at a 70% scale of the original catheter
Electrodes were attached to the surface of the sample perfused in the air instead of in blood
Rabbit ventricle wall is smoother than human atrial wall

Cite This Study

Tomii et al. (2020) studied this question.

synapsesocial.com/papers/6a0ec195aa1655e5fb22c161 https://doi.org/10.1253/circj.cj-19-1020

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Validation of Intraoperative Catheter Phase Mapping Using a Simultaneous Optical Measurement System in Rabbit Ventricular Myocardium

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Validation of Intraoperative Catheter Phase Mapping Using a Simultaneous Optical Measurement System in Rabbit Ventricular Myocardium

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

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