Pulmonary vein isolation plus ablation of selective atrial low-voltage sites significantly increased single-procedural arrhythmia freedom compared to PVI alone in persistent AF (69% vs 47%, P<0.001).
Cohort (n=151)
Does pulmonary vein isolation plus ablation of selective low-voltage areas improve arrhythmia freedom in patients with persistent atrial fibrillation?
Targeting selective low-voltage areas in addition to pulmonary vein isolation significantly improves arrhythmia-free survival in patients with persistent atrial fibrillation compared to PVI alone.
Absolute Event Rate: 69% vs 47%
p-value: p=< 0.001
BACKGROUND: Complex-fractionated atrial electrograms and atrial fibrosis are associated with maintenance of persistent atrial fibrillation (AF). We hypothesized that pulmonary vein isolation (PVI) plus ablation of selective atrial low-voltage sites may be more successful than PVI only. METHODS AND RESULTS: A total of 85 consecutive patients with persistent AF underwent high-density atrial voltage mapping, PVI, and ablation at low-voltage areas (LVA 70% of AF cycle length on a single electrode (fractionated activity) or multiple electrodes around the circumferential mapping catheter (rotational activity) or discrete rapid local activity (group I). The procedural end point was AF termination. Arrhythmia freedom was compared with a control group (66 patients) undergoing PVI only (group II). PVI alone was performed in 23 of 85 (27%) patients of group I with low amount (< 10% of left atrial surface area) of atrial low voltage. Selective atrial ablation in addition to PVI was performed in 62 patients with termination of AF in 45 (73%) after 11 ± 9 minutes radiofrequency delivery. AF-termination sites colocalized within LVA in 80% and at border zones in 20%. Single-procedural arrhythmia freedom at 13 months median follow-up was achieved in 59 of 85 (69%) patients in group I, which was significantly higher than the matched control group (31/66 47%, P < 0.001). There was no significant difference in the success rate of patients in group I with a low amount of low voltage undergoing PVI only and patients requiring PVI+selective low-voltage ablation (P = 0.42). CONCLUSIONS: Ablation of sites with distinct activation characteristics within/at borderzones of LVA in addition to PVI is more effective than conventional PVI-only strategy for persistent AF. PVI only seems to be sufficient to treat patients with left atrial low voltage < 10%.
Jadidi et al. (2016) conducted a cohort in persistent atrial fibrillation (n=151). PVI plus ablation of selective atrial low-voltage sites vs. PVI only was evaluated on Single-procedural arrhythmia freedom (p=< 0.001). Pulmonary vein isolation plus ablation of selective atrial low-voltage sites significantly increased single-procedural arrhythmia freedom compared to PVI alone in persistent AF (69% vs 47%, P<0.001).