SPAmix: a scalable, accurate, and universal analysis framework for large-scale genetic association studies in admixed populations

This is the authors' abstract. We don't add key points for this paper.

BACKGROUND: Inclusion of individuals with diverse or admixed genetic ancestries is crucial to discover novel findings that may be missed by genomics analyses rooted solely in European population. RESULTS: via Cauchy combination. CONCLUSIONS: is an optimal unified approach for various cross-ancestry genetic architectures. Extensive simulation studies and real data analyses of 369,314 UK Biobank individuals from multiple ancestries demonstrated that SPAmix is scalable and can discover novel hits while controlling type I error rates well.