December 6, 2005Annals of Internal Medicine
A Community-Based Study of Stroke Incidence after Myocardial Infarction
Key result
Incident myocardial infarction was associated with a 44-fold increased risk of stroke in the first 30 days compared to the general population (SMR 44; 95% CI, 32 to 59).
Population
2,160 persons with incident myocardial infarction between 1979 and 1998 in Olmsted County, Minnesota.
Design
Cohort
Follow-up
median of 5.6 years (range, 0 to 22.2 years)
Authors
Discussion
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Implication
May warrant closer post-MI stroke surveillance in the acute period; leaves open optimal preventive strategies pending randomized data.
Study Design
Type
Cohort (n=2,160)
Multicenter
No
Structured PICO
P
Population
2,160 persons with incident (first-ever) myocardial infarction between 1979 and 1998 in Olmsted County, Minnesota.
C
Comparator
Expected risk in the population of Rochester, Minnesota without MI
O
Outcome
Ischemic or hemorrhagic stroke in hospitalized and nonhospitalized patientshard clinical
Main Result
Effect estimate: SMR 44 (95% CI 32 to 59)
The risk of stroke is markedly increased early after an incident MI compared to the general population, and experiencing a stroke significantly increases the risk of subsequent death.
Limitations
- Findings may not be generalizable to different populations
- Outcomes were measured by reviewing medical records
- The authors measured outcomes by reviewing medical records
Cite This Study
Witt et al. (2005) conducted a cohort in Incident myocardial infarction (n=2,160). Incident myocardial infarction vs. Population of Rochester, Minnesota was evaluated on Ischemic or hemorrhagic stroke (SMR 44, 95% CI 32 to 59). Incident myocardial infarction was associated with a 44-fold increased risk of stroke in the first 30 days compared to the general population (SMR 44; 95% CI, 32 to 59).