Key result
Noninvasive scintigraphic phase image analysis completely matched the electrical epicardial activation sequence or demonstrated good agreement in approximately 85% of pacing episodes in normal and infarcted dogs.
Why the study?
Does scintigraphic phase image analysis accurately reflect the sequence of myocardial electrical activation in normal and infarcted canine models?
Does scintigraphic phase image analysis accurately reflect the sequence of myocardial electrical activation in normal and infarcted canine models?
Scintigraphic phase image analysis accurately determines the sequence of ventricular contraction and correlates strongly with epicardial electrical activation in both normal and infarcted canine hearts.
Answers are grounded in this paper and cite their sources.
Provides preclinical support for scintigraphic phase analysis in activation mapping; leaves open translation to human electrophysiology.
BACKGROUND: Phase imaging derived from equilibrium radionuclide angiography presents the ventricular contraction sequence. It has been widely but only indirectly correlated with the sequence of electrical myocardial activation. OBJECTIVES: We sought to determine the specific relationship between the sequence of phase progression and the sequence of myocardial activation, contraction and conduction, in order to document a noninvasive method that could monitor both. METHODS: In 7 normal and 9 infarcted dogs, the sequence of phase angle was correlated with the epicardial activation map in 126 episodes of sinus rhythm and pacing from three ventricular sites. RESULTS: In each episode, the site of earliest phase angle was identical to the focus of initial epicardial activation. Similarly, the serial contraction pattern by phase image analysis matched the electrical epicardial activation sequence completely or demonstrated good agreement in approximately 85% of pacing episodes, without differences between normal or infarct groups. CONCLUSIONS: A noninvasive method to accurately determine the sequence of contraction may serve as a surrogate for the associated electrical activation sequence or be applied to identify their differences.
No takes yet. Share an insight, caveat, or question.
Romeral et al. (2009) studied Myocardial contraction and electrical excitation (Animal model) (n=16). Scintigraphic phase image analysis (ERNA) vs. Epicardial activation map (EAM) was evaluated on Agreement between serial contraction pattern by phase image analysis and electrical epicardial activation sequence (p=<0.01). Noninvasive scintigraphic phase image analysis completely matched the electrical epicardial activation sequence or demonstrated good agreement in approximately 85% of pacing episodes in normal and infarcted dogs.
Synapse has enriched 10 related papers. Consider them for comparative context: