Key result
Systemic lupus erythematosus is linked to cardiac conduction defects in ~50% of patients.
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Systemic lupus erythematosus is associated with significant cardiac conduction abnormalities, including congenital heart block in neonates and QT prolongation or sinus tachycardia in adults, highlighting the need for clinical vigilance.
Systemic autoimmune conditions may cause morbidity and mortality. Systemic lupus erythematosus (SLE) is a prominent example of such diseases. It can result in conduction abnormalities due to accelerated atherosclerosis, vasculitis, or autoantibodies-induced myocarditis. Cardiac conduction abnormalities may produce sinus tachycardia, sinus bradycardia, prolonged QT intervals, atrial fibrillation, or atrioventricular (AV) nodal blocks. Neonatal lupus is sometimes associated with anti-Ro/SSA and anti-La/SSB antibodies, but their role remains a matter of controversy in adults.
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Butt et al. (2020) conducted a review in Systemic Lupus Erythematosus. Cardiac conduction defects, including congenital heart blocks in neonates and QT prolongation or myocarditis in adults, are observed in up to 50% of patients with systemic lupus erythematosus.
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