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April 1, 1973HeartOpen Access

Prevalence of three cardinal risk factors in a random sample of men and in patients with ischaemic heart disease.

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Authors

TDTravis B. DickUniversity of RochesterMSM. C. StoneRothamsted Research

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Implication

Comparative study reveals smoking and hyperlipidaemia drive coronary risk in men, highlighting the synergistic impact of smoking on cardiovascular disease.

Key Points

  • To assess and compare the prevalence of hyperlipidaemia, hypertension, and smoking in a general population sample and in men with ischaemic heart disease.
  • Assessed a 1-in-2 random sample from a general practice of 2,800 individuals, focusing on men aged 30 to 69 years.
  • Compared general practice subjects to an age- and sex-matched cohort of patients with diagnosed ischaemic heart disease.
  • Conducted lipoprotein analyses using membrane filtration and nephelometry alongside assessments of blood pressure and smoking history.
  • The prevalence of all three risk factors was elevated in patients with ischaemic heart disease, reaching statistical significance for hyperlipidaemia and smoking.
  • The combination of hyperlipoproteinaemia and hypertension in the absence of smoking showed no significant correlation with ischaemic heart disease.
  • The addition of smoking to either hypertension or hyperlipoproteinaemia produced a statistically significant relationship with ischaemic heart disease.

Cite This Study

Dick et al. (1973) studied this question.

synapsesocial.com/papers/6a0ed20e2eca052da647d0e6https://doi.org/10.1136/hrt.35.4.381
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  4. 4Coronary Heart Disease among Minnesota Business and Professional Men Followed Fifteen Years1963 · 296 citations