Key result
High triglyceride glucose index linked to ~157% greater risk of coronary calcification in ACS patients.
Why the study?
High TyG index level is a known risk for cardiovascular events, but its correlation with plaque characteristics and calcification types determined by IVUS in ACS patients required examination.
Does a high triglyceride glucose (TyG) index correlate with adverse calcification patterns and plaque vulnerability in patients with acute coronary syndrome?
Cross-Sectional (n=234)
No
Does a high triglyceride glucose (TyG) index correlate with adverse calcification patterns and plaque vulnerability in patients with acute coronary syndrome?
The TyG index is independently associated with vulnerable plaque characteristics and coronary calcification in ACS patients, suggesting its potential utility as a non-invasive biomarker for risk stratification.
Answers are grounded in this paper and cite their sources.
TyG index was associated with calcification and small lumen area in ACS; leaves open its role as a non-invasive biomarker.
PURPOSE: High triglyceride glucose (TyG) index level is one of the risks for cardiovascular events. The purpose of this research was to examine the correlation of the triglyceride glucose (TyG) index levels with plaque characteristics and calcification types determined by intravascular ultrasound (IVUS) in acute coronary syndrome (ACS) patients. METHODS: A total of 234 acute coronary syndromes (ACS) participants who completed intravascular ultrasound (IVUS) and coronary angiography (CAG) were finally enrolled. RESULTS: Logistic regression analysis manifested that the TyG index was independently correlated with the occurrence of coronary calcification, minimum lumen area (MLA) ≤ 4.0 mm², plaque burden (PB) > 70%, and spotty calcification. Taking the lowest group as a reference, the risk of coronary calcification (OR, 2.57; 95%CI, 1.04-6.35; p = 0.040), MLA ≤ 4.0 mm² (OR, 7.32; 95%CI, 2.67-20.01; p < 0.001), PB > 70% (OR, 2.68; 95%CI, 1.04-6.91; p = 0.041), and spotty calcification (OR, 1.48; 95%CI, 0.59-3.71; p = 0.407) was higher in the highest TyG index group. TyG index was converted into a dichotomous variable or a continuous variable for analysis, and we found that a similar result was observed. In addition, optimal predictive models consisting of clinical variables and the TyG index distinctly improved the ability to predict the prevalence of coronary calcification and MLA ≤ 4.0 mm² (p < 0.05). CONCLUSION: The TyG index may serve as a potential predictor for calcification patterns and plaque vulnerability.
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Yin et al. (2023) conducted a cross-sectional in Acute coronary syndrome (n=234). High Triglyceride glucose (TyG) index vs. Lowest TyG index tertile (T1) was evaluated on Coronary calcification (OR 2.57, 95% CI 1.04-6.35, p=0.040). A high triglyceride glucose index was independently associated with an increased risk of coronary calcification (OR 2.57) and minimum lumen area ≤ 4.0 mm² (OR 7.32) in patients with acute coronary syndrome.
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