Key result
Midlife low and high diastolic blood pressure and mean arterial pressure demonstrated a U-shaped association with an increased risk of cognitive impairment 20 years later.
Why the study?
Does midlife hypertensive status predict cognitive impairment 20 years later in a multiethnic population?
Cohort (n=1,484)
Yes
Does midlife hypertensive status predict cognitive impairment 20 years later in a multiethnic population?
Effect estimate: OR 1.13 (95% CI 1.05-1.22)
p-value: p=0.002
Both low and high midlife diastolic blood pressure and mean arterial pressure are associated with an increased risk of cognitive impairment 20 years later.
No takes yet. Share an insight, caveat, or question.
Should not yet change midlife BP targets; leaves open causal effects in multiethnic cohorts.
Taylor et al. (2013) conducted a cohort in Cognitive Impairment (n=1,484). Midlife blood pressure levels and antihypertensive treatment was evaluated on Cognitive impairment (lowest 10% within each ethnic group) (OR 1.13, 95% CI 1.05-1.22, p=0.002). Midlife low and high diastolic blood pressure and mean arterial pressure demonstrated a U-shaped association with an increased risk of cognitive impairment 20 years later.
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