Key result
Spontaneous MI within 6 months increased 5-year cardiovascular mortality (HR 4.52; 95% CI 3.37-6.06; P<0.001), whereas procedure-related MI did not (HR 0.66; 95% CI 0.36-1.20; P=0.17).
Why the study?
Does procedure-related or spontaneous myocardial infarction impact long-term cardiovascular mortality in patients with non-ST-elevation acute coronary syndrome?
Cohort (n=5,467)
Yes
Does procedure-related or spontaneous myocardial infarction impact long-term cardiovascular mortality in patients with non-ST-elevation acute coronary syndrome?
Effect estimate: HR 0.66 (95% CI 0.36-1.20)
p-value: p=0.17
In patients with non-ST-elevation acute coronary syndrome, spontaneous myocardial infarction is associated with a substantial increase in long-term cardiovascular mortality, whereas procedure-related myocardial infarction is not.
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Spontaneous MI signals higher long-term CV mortality after NSTE-ACS; leaves open subtype-specific risk stratification and management.
Damman et al. (2011) conducted a cohort in Non-ST-segment elevation acute coronary syndrome (n=5,467). Procedure-related myocardial infarction vs. No procedure-related myocardial infarction was evaluated on Cardiovascular death up to 5 years of follow-up (HR 0.66, 95% CI 0.36-1.20, p=0.17). Spontaneous MI within 6 months increased 5-year cardiovascular mortality (HR 4.52; 95% CI 3.37-6.06; P<0.001), whereas procedure-related MI did not (HR 0.66; 95% CI 0.36-1.20; P=0.17).
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