Key result
Ventricular pre-excitation is not linked to increased overall mortality in primary care.
Why the study?
Although invasive risk stratification is well established for symptomatic ventricular pre-excitation, evidence of benefit in asymptomatic patients is lacking.
Does the presence of ventricular pre-excitation on ECG increase the risk of overall mortality in primary care patients?
Population
Nearly 1 665 667 primary care patients in Brazil
Comparison
Ventricular pre-excitation vs whole sample or normal ECG
Design
Observational electronic cohort study
Follow-up
Mean 3.7 years
Authors
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Should not yet change practice for asymptomatic pre-excitation; leaves open arrhythmic risk in unselected cohorts.
Observational (n=1,665,667)
Yes
Does the presence of ventricular pre-excitation on ECG increase the risk of overall mortality in primary care patients?
Effect estimate: HR 1.41 (95% CI 0.56-3.57)
p-value: p=0.47
Ventricular pre-excitation on ECG is not associated with an increased risk of overall mortality in a large primary care cohort, suggesting that asymptomatic patients may not require invasive risk stratification.
Paixão et al. (2021) conducted an observational in Ventricular pre-excitation (n=1,665,667). Ventricular pre-excitation vs. Whole sample or normal ECG was evaluated on overall mortality (HR 1.41, 95% CI 0.56-3.57, p=0.47). Ventricular pre-excitation was not associated with an increased risk of overall mortality compared to the whole sample in a primary care cohort (HR 1.41; 95% CI 0.56-3.57; p=0.47).
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