Key result
Impaired collagen degradation in mice prevents RV collagen accumulation and limits hypertrophy despite elevated systolic pressure.
Why the study?
Does impaired collagen degradation improve right ventricular structure and function in a mouse model of pulmonary arterial hypertension?
Population
Mutant (Col1a1) mice and wild-type (Col1a1) littermates exposed to 14 days of chronic hypoxia combined with…
Comparison
Col1a1 mutation causing impaired collagen type I… vs Wild-type (Col1a1(+/+)) littermates
Design
Preclinical
Follow-up
14 days
Authors
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Should not yet change practice in pulmonary hypertension; leaves open whether targeting collagen degradation protects the right ventricle.
Does impaired collagen degradation improve right ventricular structure and function in a mouse model of pulmonary arterial hypertension?
Absolute Event Rate: 47% vs 46%
Limiting collagen turnover via impaired degradation preserves right ventricular function and limits hypertrophy in a mouse model of pulmonary arterial hypertension, suggesting a potential novel therapeutic strategy.
Golob et al. (2016) studied Pulmonary arterial hypertension. Col1a1(R/R) mutation (impaired collagen type I degradation) vs. Wild-type (Col1a1(+/+)) littermates was evaluated on Right ventricular systolic pressure (mmHg). Impaired collagen degradation in Col1a1(R/R) mice prevented RV collagen accumulation and limited RV hypertrophy despite comparable increases in RV systolic pressure (47 vs 46 mmHg).
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