January 1, 1995Thrombosis and Haemostasis
Optimal Duration of Oral Anticoagulant Therapy: A Randomized Trial Comparing Four Weeks with Three Months of Warfarin in Patients with Proximal Deep Vein Thrombosis
Key result
The provided text consists only of journal editorial board information and does not contain the clinical trial results comparing four weeks versus three months of warfarin.
Why the study?
Does continuing warfarin for 3 months compared to 4 weeks reduce recurrent VTE in patients with acute proximal DVT and a normal 4-week IPG?
Population
214 patients with venographically confirmed acute proximal deep vein thrombosis who had received four weeks…
Comparison
Warfarin continued for a further 8 weeks. vs Placebo for a further 8 weeks.
Design
RCT, Allocated to either continue warfarin or receive placebo…
Follow-up
11 months
Authors
Discussion
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Implication
Extending warfarin to 3 months reduces short-term recurrent VTE after proximal DVT; extends evidence that ongoing risk factors outweigh normal IPG for long-term recurrence.
Study Design
Type
RCT
Structured PICO
Does continuing warfarin for 3 months compared to 4 weeks reduce recurrent VTE in patients with acute proximal DVT and a normal 4-week IPG?
P
Population
214 patients with venographically confirmed acute proximal deep vein thrombosis (DVT) who had received four weeks of warfarin after initial heparin and whose four-week impedance plethysmogram (IPG) was normal.
I
Intervention
Warfarin (targeted International Normalized Ratio 2.0 to 3.0) continued for a further 8 weeks (total 3 months of therapy).
C
Comparator
Placebo for a further 8 weeks (total 4 weeks of active warfarin therapy).
O
Outcome
Recurrent venous thromboembolism (VTE) during the 8 weeks following randomization and over 11 months of follow-up.hard clinical
Continuing warfarin for 3 months compared to 4 weeks reduces short-term recurrent VTE, but the presence of continuing clinical risk factors is a stronger predictor of long-term recurrence than a normal IPG.
Cite This Study
Levine et al. (1995) conducted an RCT in Proximal Deep Vein Thrombosis. Warfarin vs. Warfarin (3 months) was evaluated. The provided text consists only of journal editorial board information and does not contain the clinical trial results comparing four weeks versus three months of warfarin.