Among 105 presumably healthy males with positive non-invasive tests for coronary heart disease, 34.3% had less than 50% coronary obstruction on angiography.
Cross-Sectional (n=105)
What is the rate of significant coronary obstruction and false positive non-invasive tests in presumably healthy males with suspected CHD?
In presumably healthy middle-aged men with positive non-invasive tests for CHD, approximately one-third have false-positive results without significant coronary obstruction on angiography.
Among 2014 presumably healthy males aged 40-59 years coronary heart disease (CHD) was suggested in 115 in the presence of one or more of the following criteria: 1) a WHO-questionnaire on angina pectoris positive on interview, 2) typical angina during a near maximal bicycle exercise test, 3) a positive exercise ECG during and/or post exercise, 4) a Minnesota Code 1.1 on a resting ECG. Diagnostic coronary angiography was offered to all 115 CHD-suspect cases. Six refused angiography and four others were excluded. Of the remaining 105, thirty-six had less than 50% obstruction of any major coronary artery (34.3%). Eighteen (17.1%) had single, 25 (23.8%) had double and 26 (24.8%) had triple vessel disease. In 62 of the 69 with pathologic angiograms at least one obstruction greater than or equal to 75% was found. Eighty percent of the cases with proven CHD were greater than or equal to 50 years. All CHD-suggestive criteria had approximately the same diagnostic performance regardless of age, i.e., approximately one false positive/two true positives. Except for one retroperitoneal hematoma no complications to angiography occurred.
Erikssen et al. (Wed,) conducted a cross-sectional in Suspected coronary heart disease (n=105). Non-invasive diagnostic tests for CHD was evaluated on Less than 50% obstruction of any major coronary artery (false positive). Among 105 presumably healthy males with positive non-invasive tests for coronary heart disease, 34.3% had less than 50% coronary obstruction on angiography.