Key result
Coronary vein ligation triggers acute myocardial cell edema, mitochondrial disruption, and autophagy in minipigs.
Why the study?
Unlike coronary artery disease, coronary vein disease is rarely studied, yet coronary venous dysfunction may explain suspicious coronary symptoms in patients without coronary artery spasm or obvious angiographic stenosis.
Does acute coronary vein ligation cause ultrastructural damage to myocardial cells in normal miniature pigs?
Does acute coronary vein ligation cause ultrastructural damage to myocardial cells in normal miniature pigs?
Answers are grounded in this paper and cite their sources.
Acute ligation of the middle cardiac vein in minipigs induces rapid ultrastructural cardiomyocyte and mitochondrial injury within 4 hours, suggesting that coronary venous occlusion could contribute to myocardial dysfunction and angina despite normal coronary arteries.
Background: The study of coronary artery disease has been quite thorough. But there is few study on coronary vein disease. In clinical practice, some patients have suspicious symptoms of coronary artery disease without any evidence of coronary artery spasm, but coronary angiography showed no obvious stenosis in coronary artery. It may have relationship to coronary venous dysfunction. This study aims to develop a coronary vein ligation model, to investigate the effect of coronary vein occlusion on myocardial cells in normal miniature pigs. Methods: Adult minifies were divided into control group and intervention group. The coronary venous occlusion model was made by clamping the central vein. Myocardium was isolated from the myocardium and the myocardium was observed by transmission electron microscopy. Results: There were no significant changes in the sham operation group (control group). Mitochondrial edema, cristae broken, hyperplasia and auto phage some appeared in the operation group (intervention group). Conclusion: The ligation of the coronary vein causes dysfunction of myocardial cells. It gives us inspiration, coronary vein occlusive disease may be underestimated. It may be some causes of angina for patients with normal coronary angiography.
No takes yet. Share an insight, caveat, or question.
Chu Yinjie (2017) studied Coronary vein occlusion model in normal miniature pigs (n=6). Coronary vein ligation (middle cardiac vein proximal to the coronary sinus) vs. Sham operation (opening the chest with 7-O polypropylene suture encircling the middle cardiac vein without ligation) was evaluated on Ultrastructural changes of myocardial cells observed by transmission electron microscopy (TEM). Coronary vein ligation for 4 hours caused myocardial cell edema, mitochondrial cristae breakage, hyperplasia, and autophagy in minipigs (n=5) compared to no significant changes in sham control (n=1).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: