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January 1, 2008Circulation JournalOpen Access

Prognosis and Prognostic Factors in Patients With Idiopathic Dilated Cardiomyopathy in Japan Results From a Nationwide Study

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Population

1,554 patients with idiopathic dilated cardiomyopathy (IDC) in Japan, diagnosed in 1998.

Design

Cohort

Follow-up

5 years

Key result

Idiopathic dilated cardiomyopathy had a 5-year survival rate of 78.6%, with older age, male sex, higher NYHA class, higher LV diameter index, and lower LVEF independently predicting mortality.

Authors

KMKatsuyuki MiuraAMAkira MatsumoriANAli Nasermoaddeli

Discussion

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Overview

May aid prognostic discussions in idiopathic dilated cardiomyopathy; leaves open prospective validation of the 5-variable score.

Study Design

Type

Cohort (n=1,554)

Multicenter

Yes

Structured PICO

P
Population
1,554 patients with idiopathic dilated cardiomyopathy (IDC) in Japan, diagnosed in 1998.
O
Outcome
All-cause mortality (5-year survival rate)hard clinical

A simple 5-variable clinical score (age, sex, NYHA class, LV diameter index, and LVEF) can effectively predict 5-year survival in patients with idiopathic dilated cardiomyopathy.

Limitations

  • Failed to differentiate cardiovascular deaths from other causes of mortality
  • Methods used for various measurements were not fully standardized
  • Findings from cardiac catheterization, cardiac biopsy, and blood biomarkers were not considered
  • Medical treatment was not taken into consideration
  • Selection bias due to a relatively small number of departments participating in the follow-up survey
  • Prediction of prognosis using the predictive score may be difficult to generalize to IDC patients in other countries
  • Possible selection bias due to a relatively small number of departments participating in the follow-up survey
  • Difficult to generalize to IDC patients in other countries

Cite This Study

Miura et al. (2008) conducted a cohort in Idiopathic dilated cardiomyopathy (n=1,554). None (Observational) was evaluated on 5-year survival rate. Idiopathic dilated cardiomyopathy had a 5-year survival rate of 78.6%, with older age, male sex, higher NYHA class, higher LV diameter index, and lower LVEF independently predicting mortality.

synapsesocial.com/papers/6a0f3506c29d3e682ebdb619https://doi.org/10.1253/circj.72.343
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