Key result
Coxsackievirus B3 infection of human cells altered the expression of specific host proteins, including nucleophosmin, lamin, UNR, and p38 MAPK, which are relevant to the myocarditis process.
Why the study?
Does coxsackievirus B3 infection alter the proteome of human host cells?
Does coxsackievirus B3 infection alter the proteome of human host cells?
This study identifies specific host protein responses to coxsackievirus B3 infection, providing insights into the molecular mechanisms of viral myocarditis.
Coxsackievirus B3 (CVB3) is a common factor in human myocarditis. The interplay between host factors and virus components is crucial for the fate of the infected cells. Despite that, host protein responses, which characterize CVB3-induced diseases, have not yet been determined in detail. To investigate the nature of modified protein patterns in infected human cells compared with uninfected cells, two-dimensional gel electrophoresis in combination with matrix-assisted laser desorption/ionization-mass spectrometry were used. The regulated proteins, e.g. nucleophosmin (nucleolar protein B23), lamin, the RNA-binding protein UNR and the p38 mitogen-activated protein kinase, were sorted according to their functional groups and interpreted in the context of the myocarditis process.
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Rassmann et al. (2006) studied Coxsackievirus B3 infection / myocarditis. Coxsackievirus B3 (CVB3) infection vs. Uninfected human cells was evaluated on Modified protein patterns (proteome alterations). Coxsackievirus B3 infection of human cells altered the expression of specific host proteins, including nucleophosmin, lamin, UNR, and p38 MAPK, which are relevant to the myocarditis process.
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