We found that DNA molecules bind strongly to zwitterionic dipalmitoylphosphatidylcholine lipid bilayers in solutions, facilitating in situ imaging with an atomic force microscope. The binding strength has a lower limit of about 2 kT per helical turn with kT the thermal energy at room temperature. The height of membrane-bound DNA is the same as the diameter of DNA, indicating no compression by the tip at a probe force of about 0.1 nN.
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Malghani et al. (1998) studied this question.
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