Key result
Elevated blood ketones correlate with cardiac dysfunction severity and offer prognostic value in HF.
Why the study?
Heart failure progression involves metabolic and physiologic adaptations, prompting an exploration of metabolic changes and the potential role of biomarkers, particularly ketone bodies, in staging and prognosticating heart failure.
Ketone bodies serve as prognostic biomarkers in heart failure and represent a potential avenue for therapeutic intervention by targeting myocardial metabolic adaptation.
Hypothesis-generating for ketones as HF biomarkers; leaves open therapeutic targeting in prospective trials.
PURPOSE OF REVIEW: The development and progression of heart failure is characterized by metabolic and physiologic adaptations allowing patients to cope with cardiac insufficiency. This review explores the changes in metabolism in heart failure and the potential role of biomarkers, particularly ketone bodies, in staging and prognosticating heart failure progression. RECENT FINDINGS: Recent insights into myocardial metabolism shed light on the heart's response to stress, highlighting the shift towards reliance on ketone bodies as an alternative fuel source. Elevated blood ketone levels have been shown to correlate with the severity of cardiac dysfunction, emphasizing their potential as prognostic indicators. Furthermore, studies exploring therapeutic interventions targeting specific metabolic pathways offer promise for improving outcomes in heart failure. Ketones have prognostic utility in heart failure, and potentially, an avenue for therapeutic intervention. Challenges remain in deciphering the optimal balance between metabolic support and exacerbating cardiac remodeling. Future research endeavors must address these complexities to advance personalized approaches in managing heart failure.
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Foster et al. (2024) conducted a review in Heart failure. Ketone bodies was evaluated. Elevated blood ketone levels correlate with the severity of cardiac dysfunction, emphasizing their potential as prognostic indicators and therapeutic targets in heart failure.
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