Key result
Novel warfarin dosing algorithm outperforms 21 published models in Korean patients with VKORC1 1173C.
Why the study?
Does a novel genotype-guided warfarin dosing algorithm improve dose prediction in Korean patients with VKORC1 1173C compared to previously published algorithms?
Observational (n=109)
Does a novel genotype-guided warfarin dosing algorithm improve dose prediction in Korean patients with VKORC1 1173C compared to previously published algorithms?
Effect estimate: ρ=0.641
A novel genotype-guided warfarin dosing algorithm demonstrated superior predictive performance for maintenance dosing in Korean patients with the VKORC1 1173C variant compared to existing algorithms.
May improve dose prediction in Korean VKORC1 1173C patients; leaves open outcome benefits in prospective trials.
BACKGROUND: 1173C. METHODS: 1173CT (N=105) or 1173CC (N=4) were included in this study. Multiple regression analysis was performed to deduce a new dosing algorithm. Following literature searches for genotype-guided warfarin dosing algorithms, 21 algorithms were selected and evaluated using the correlation coefficient (ρ) of actual dose and estimated dose, mean error, and root mean square error. RESULTS: genotype)]. Integrated variables explained 44% of the variance in the maintenance dose. The predicted and actual doses showed moderate correlation (ρ=0.641) with the best performance with a mean error of -1.30 mg/week. The proportion of underestimated groups was 17%, which was lower than with the other algorithms. CONCLUSIONS: 1173C carriers; it showed superior predictive performance compared with previously published algorithms.
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Cho et al. (2019) conducted an observational in Patients requiring warfarin with VKORC1 1173C genotype (n=109). Novel warfarin dosing algorithm vs. 21 previously published algorithms was evaluated on Correlation coefficient of actual dose and estimated dose, mean error, and root mean square error (ρ=0.641). A novel warfarin dosing algorithm for Korean patients with VKORC1 1173C showed moderate correlation (ρ=0.641) with actual doses and superior predictive performance versus 21 published algorithms.
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