Why the study?
Does the addition of von Willebrand factor to current risk stratification scores improve event-risk prediction in anticoagulated patients with non-valvular atrial fibrillation?
Population
1215 consecutive outpatients with anticoagulated non-valvular atrial fibrillation, age 76 years, 49% male.
Comparison
Addition of von Willebrand factor measurement to… vs Clinical risk stratification schemes alone
Design
Cohort
Follow-up
almost 7 years
Authors
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Minimal net benefit precludes routine vWF addition to AF scores; extends associations but leaves clinical utility open pending validation.
Does the addition of von Willebrand factor to current risk stratification scores improve event-risk prediction in anticoagulated patients with non-valvular atrial fibrillation?
While von Willebrand factor is associated with adverse outcomes in anticoagulated AF patients, its addition to standard risk scores provides marginal absolute improvements in risk prediction and clinical decision-making.
García-Fernández et al. (2017) studied this question.
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