Key result
Clopidogrel in PAD is linked to lower oxidized protein and higher SOD concentrations.
Why the study?
Oxidative stress plays a crucial role in PAD pathogenesis, but the effect of clopidogrel on oxidative stress in these patients remained to be investigated.
Does clopidogrel improve oxidative stress biomarkers in patients with peripheral artery disease?
Observational (n=70)
Does clopidogrel improve oxidative stress biomarkers in patients with peripheral artery disease?
Clopidogrel treatment in PAD patients may have antioxidant efficacy, evidenced by decreased oxidized protein levels despite low active SOD enzyme ratios.
Clopidogrel was associated with reduced oxidative stress markers in PAD; leaves open clinical relevance and need for RCTs.
Oxidative stress plays a crucial role in the pathogenesis of peripheral artery disease (PAD). This study aimed to investigate the effect of clopidogrel on oxidative stress in PAD patients. Seventy subjects were divided into three groups: PAD patients before treatment (B-PAD), PAD patients after treatment with clopidogrel (A-PAD), and healthy controls. Serum levels of superoxide dismutase (SOD), copper (Cu), zinc (Zn), manganese (Mn), and oxidized protein were measured. SOD activities were also determined. The results showed that SOD activities, and SOD specific activities were significantly decreased in PAD patients compared to healthy individuals. After treatment with clopidogrel, SOD activities, and SOD specific activities were continuously decrease in PAD patients. The SOD and oxidized protein concentrations were significantly increased in PAD patients compared to healthy individuals. After treatment with clopidogrel, the oxidized protein concentration was significantly decreased, while SOD concentration was significantly increased in PAD patients. These findings suggest that the treatment by clopidogrel stimulated the production of the enzyme but the ratio of active enzyme remained low. The decrease in oxidized protein can be explained by the treatment having antioxidant efficacy that may have compensated for the deficiency in enzyme activity and led to a decrease in oxidized protein. Additionally, the results of this study provide promising evidence that oxidative stress biomarkers including SOD concentration, T-SOD activity, Mn-SOD activity, and oxidized protein levels have potential utility in the diagnosis and management of PAD.
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Fakhri et al. (2024) conducted an observational in Peripheral artery disease (PAD) (n=70). Clopidogrel vs. Before treatment and healthy controls was evaluated on Serum levels of superoxide dismutase (SOD), copper, zinc, manganese, oxidized protein, and SOD activities. Clopidogrel treatment in peripheral artery disease patients significantly decreased oxidized protein and increased SOD concentrations, though SOD specific activities remained low.
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