Key result
Persistent Fontan fenestration patency linked to ~2% greater oxygen desaturation at peak exercise vs nonfenestration.
Why the study?
Does persistent Fontan fenestration patency affect cardiopulmonary exercise testing variables in patients with Fontan circulation?
Cross-Sectional
Yes
Does persistent Fontan fenestration patency affect cardiopulmonary exercise testing variables in patients with Fontan circulation?
Absolute Event Rate: -4.9% vs -3%
p-value: p=< .001
Persistent Fontan fenestration patency has minimal effects on cardiopulmonary exercise testing measurements, primarily causing a slightly greater decrease in oxygen saturation and higher physiological dead space at peak exercise.
Minimal effects on exercise testing in Fontan patients; leaves open whether fenestration closure alters outcomes.
Cardiopulmonary exercise testing (CPET) aids in clinical assessment of patients with Fontan circulation. Effects of persistent fenestration on CPET variables have not been clearly defined. Associations between fenestration and CPET variables at anaerobic threshold (AT) and peak exercise were explored in the Pediatric Heart Network Fontan Cross-Sectional Study cohort. Fenestration patency was associated with a greater decrease in oxygen saturation from rest to peak exercise (fenestration -4.9 ± 3.8 v. nonfenestration -3 ± 3.5; P < .001). Physiological dead space at peak exercise was higher in fenestrated v. nonfenestrated (25.2 ± 16.1 v. 21.4 ± 15.2; P = .03). There was a weak association between fenestration patency and maximal work and heart rate. Fenestration patency was also weakly correlated with oxygen pulse, work and VE/VCO2 at AT. The effect of persistent fenestration on CPET measurements was minimal in this study, likely due to the cross-sectional design.
No takes yet. Share an insight, caveat, or question.
Heal et al. (2017) conducted a cross-sectional in Fontan circulation. Persistent Fontan fenestration patency vs. Nonfenestration was evaluated on Decrease in oxygen saturation from rest to peak exercise (p=< .001). Persistent Fontan fenestration patency was associated with a greater decrease in oxygen saturation from rest to peak exercise (-4.9 vs -3.0; P<0.001) compared to nonfenestration.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: