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Methodology study demonstrates a log-logistic model to evaluate drug synergy while adjusting for plate-location bias in oncology assays, highlighting improved accuracy for high-throughput screening.
In this paper we present and discuss a novel, simple and easy to implement parametric modeling approach to assess synergy. An extended three parameter log-logistic model is used to analyse the data and calculate confidence intervals of the interaction indices. In addition the model corrects for the bias due to plate-location effects. The analysis is performed with PROC NLMIXED and SAS-code is provided. The approach is illustrated using data coming from an oncology study in which the inhibition effect of a combination of two compounds is studied using 96-well plates and a fixed-ratio design.
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Straetemans et al. (2005) studied this question.
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