Key result
Members of the hnRNP H protein family bind the consensus motif DGGGD and activate splicing of an HIV-1 tat-derived substrate by promoting ATP-dependent spliceosomal complex formation.
Population
Substrate derived from the HIV-1 tat gene and members of the heterogeneous nuclear ribonucleoprotein H…
Design
Preclinical
Authors
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No immediate clinical application in HIV; leaves open hnRNP H as antiviral splicing target.
Members of the hnRNP H protein family activate splicing of an HIV-1 substrate by promoting the formation of ATP-dependent spliceosomal complexes.
Schaub et al. (2007) studied HIV-1. hnRNP H family proteins was evaluated on Splicing of a substrate derived from the HIV-1 tat gene. Members of the hnRNP H protein family bind the consensus motif DGGGD and activate splicing of an HIV-1 tat-derived substrate by promoting ATP-dependent spliceosomal complex formation.
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