May 21, 2026Journal of the American College of Cardiology
Antioxidants, statins, and atherosclerosis
Key result
Antioxidants show no consistent benefit over statins for coronary prevention.
Design
Review
Authors
Discussion
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Implication
The review highlights the lack of clinical benefit for antioxidants in coronary prevention compared to the established efficacy of statins and dietary modifications.
Key Points
- Assess the clinical evidence for antioxidant supplementation in coronary disease prevention relative to established lipid-lowering therapies like statins.
- Narrative review evaluating clinical studies of antioxidant interventions and their effects on coronary end points.
- Comparison of clinical outcomes between antioxidant regimens and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor (statin) therapy.
- Clinical trials demonstrate inconsistent benefits of antioxidant agents on coronary endpoints, showing little overall support for their use in cardiovascular prevention.
- Lipid-lowering interventions, including statins and Mediterranean-style dietary modifications, consistently reduce coronary events.
Structured PICO
I
Intervention
Antioxidants and statins
The review highlights the lack of clinical benefit for antioxidants in coronary prevention compared to the established efficacy of statins and dietary modifications.
Limitations
- Incomplete picture regarding the limitations of available antioxidant studies and the agents used
Cite This Study
Antonio M. Gotto (2003) conducted a review in Atherosclerosis. Antioxidants vs. Statins was evaluated on Clinical coronary end points. Antioxidants have shown inconsistent effects on clinical coronary endpoints, providing little support for their use in coronary prevention compared to proven strategies like statins.