Why the study?
Does the site of sodium channel blockade application relative to repolarization gradients determine its anti- or profibrillatory effects in isolated porcine hearts?
Population
Isolated porcine hearts with induced repolarization heterogeneity via selective perfusion of vascular beds
Comparison
Flecainide infusion in the pinacidil domain or… vs Baseline state prior to flecainide infusion
Design
Preclinical
Key result
Sodium channel blockade with flecainide was antifibrillatory when applied to myocardium with a short refractory period, but profibrillatory when applied to myocardium with a long refractory period.
Authors
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Site-specific flecainide effects on fibrillation may depend on local refractory period; leaves open translation to human antiarrhythmic strategies.
Does the site of sodium channel blockade application relative to repolarization gradients determine its anti- or profibrillatory effects in isolated porcine hearts?
p-value: p=<0.001
Sodium channel blockade exhibits anti- or profibrillatory effects depending on whether it is applied to myocardium with a short or long refractory period, providing a mechanistic basis for these opposing effects.
Ruben Coronel (2010) studied Ventricular fibrillation (n=8). Flecainide vs. Baseline (prior to flecainide) was evaluated on Activation time delay of basic and premature beats (S1 and S2) induced by flecainide (p=<0.001). Sodium channel blockade with flecainide was antifibrillatory when applied to myocardium with a short refractory period, but profibrillatory when applied to myocardium with a long refractory period.