Key result
Acute redistribution of septal-lateral LV myocardial work after CRT strongly correlates with volumetric reverse remodeling.
Why the study?
The acute impact of CRT on regional myocardial work distribution in the LV and its relation to long-term reverse remodelling remained to be investigated.
Does the acute redistribution of regional myocardial work by cardiac resynchronization therapy predict long-term reverse remodelling in heart failure patients?
Observational (n=130)
Yes
Does the acute redistribution of regional myocardial work by cardiac resynchronization therapy predict long-term reverse remodelling in heart failure patients?
Effect estimate: r 0.62
p-value: p=<0.0001
Acute redistribution of regional myocardial work between the septal and lateral wall is a strong determinant of long-term reverse remodelling after CRT, suggesting treatment of loading imbalance should be a primary aim.
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Acute work redistribution after CRT was associated with reverse remodelling; hypothesis-generating for prospective validation before guiding therapy.
Duchenne et al. (2020) conducted an observational in Heart failure (n=130). Cardiac resynchronization therapy (CRT) vs. Pre-implantation was evaluated on Volumetric reverse remodelling (change in LV end-systolic volume) (r 0.62, p=<0.0001). Acute redistribution of regional myocardial work between the septal and lateral wall of the LV after CRT strongly correlated with volumetric reverse remodelling (r = 0.62, P < 0.0001).
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