Key result
Due to high spontaneous variation, distinguishing a true therapeutic reduction in ventricular premature depolarizations requires a >83% reduction when comparing two 24-hour monitoring periods.
Observational (n=15)
Due to high spontaneous variability in ventricular premature depolarizations, distinguishing true therapeutic effect from biologic variation requires a greater than 83% reduction when comparing two 24-hour Holter monitors.
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Clinicians should interpret modest VPD reductions on serial Holters with caution; leaves open refined suppression thresholds for future arrhythmia trials.
Morganroth et al. (1978) conducted an observational in Ventricular premature depolarizations in various cardiac disorders (n=15). Long-term electrocardiography monitoring was evaluated on Variations in the frequency of ventricular premature depolarizations (VPDs). Due to high spontaneous variation, distinguishing a true therapeutic reduction in ventricular premature depolarizations requires a >83% reduction when comparing two 24-hour monitoring periods.
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