Key result
Valvuloarterial impedance strongly correlates with pre-AVR LV concentric remodeling and predicts post-surgical hypertrophy regression.
Why the study?
Does valvuloarterial impedance impact left ventricular hypertrophy regression after aortic valve replacement in patients with aortic stenosis?
Cohort (n=453)
No
Does valvuloarterial impedance impact left ventricular hypertrophy regression after aortic valve replacement in patients with aortic stenosis?
Effect estimate: r = 0.601
p-value: p=<0.001
Valvuloarterial impedance is a major determinant of concentric remodeling in aortic stenosis and its regression after aortic valve replacement, suggesting it should be incorporated into routine evaluation.
May refine preoperative risk stratification in aortic stenosis; extends valvuloarterial impedance associations to post-AVR hypertrophy regression but requires prospective validation.
BACKGROUND: Left ventricle (LV) in patients with aortic stenosis (AS) faces a double hemodynamic load incorporating both valvular stenosis and reduced systemic arterial compliance (SAC). This study aimed to evaluate the impact of global LV afterload on LV hypertrophy (LVH) before and after aortic valve replacement (AVR). METHODS: ) and LV mass index/LV end-diastolic volume index (LVMI/LVEDVI) as a parameter of LVH. RESULTS: < 0.001) were independent factors associated with LVH regression in 322 patients with follow-up duration >1 year after AVR. CONCLUSION: is a major determinant of concentric remodeling in AS before AVR and LVH regression after AVR, which should be incorporated in routine evaluation of AS.
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Jang et al. (2016) conducted a cohort in Severe aortic stenosis (n=453). Aortic valve replacement was evaluated on Correlation between valvuloarterial impedance (ZVA) and pre-AVR left ventricular geometry index (LVMI/LVEDVI) (r = 0.601, p=<0.001). Valvuloarterial impedance strongly correlated with left ventricular concentric remodeling before aortic valve replacement (r = 0.601) and independently predicted hypertrophy regression after surgery.
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