Key result
Elevated triglycerides post-MI are linked to a ~36% higher risk of recurrent ischemic events.
Why the study?
The characteristics and prognosis of patients with elevated triglycerides hospitalized for an acute myocardial infarction required evaluation.
Are elevated triglycerides associated with an increased risk of recurrent ischemic events in patients hospitalized for acute myocardial infarction?
Observational (n=10,667)
Yes
Are elevated triglycerides associated with an increased risk of recurrent ischemic events in patients hospitalized for acute myocardial infarction?
Elevated triglycerides (>200 mg/dL) in acute MI survivors are associated with a significantly increased risk of recurrent ischemic events at 1 year, highlighting a residual risk beyond traditional markers.
Answers are grounded in this paper and cite their sources.
Elevated TG may flag residual post-MI risk; leaves open whether TG-lowering improves outcomes.
From a large regional registry, we aimed to address the characteristics and prognosis of patients with elevated triglycerides (TG) among patients hospitalized for an acute myocardial infarction (MI). From the multicenter database of the RICO survey, all consecutive patients hospitalized for an acute MI (2001-2017) and alive at discharge were included. Among the 10,667 patients included, 17.7% had elevated TG. When compared with patients with TG ≤ 200 mg/dL, patients with high TG (>200 mg/dL) were 10 years younger, had a higher BMI, were more frequently men, diabetic, and smokers. At 1-year follow-up, recurrent ischemic events were more frequent in elevated TG patients. In multivariate logistic regression analysis, high TG (OR (95%CI): 1.356 (1.095-1.679)) remained an independent estimate for recurrent ischemic events, even after adjustment for confounding factors. In our large population-based cohort, elevated TG are common in acute MI, and associated with residual risk of recurrent ischemic events, beyond traditional prognostic markers.
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Zeller et al. (2023) conducted an observational in acute myocardial infarction (n=10,667). Elevated triglycerides (>200 mg/dL) vs. Triglycerides ≤ 200 mg/dL was evaluated on recurrent ischemic events (OR 1.356, 95% CI 1.095-1.679). Elevated triglycerides (>200 mg/dL) in acute MI patients were independently associated with a higher risk of recurrent ischemic events at 1 year (OR 1.356; 95% CI 1.095-1.679).
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