Key result
Higher atherogenic index of plasma links to ~31% greater cardiovascular risk in prediabetic unstable angina.
Why the study?
The relation between the atherogenic index of plasma and cardiovascular prognosis in prediabetic patients with unstable angina pectoris remained uncertain.
Does the atherogenic index of plasma (AIP) predict cardiovascular outcomes in prediabetic individuals with unstable angina pectoris?
Cohort (n=1,096)
No
Does the atherogenic index of plasma (AIP) predict cardiovascular outcomes in prediabetic individuals with unstable angina pectoris?
Effect estimate: HR 1.308 (95% CI 1.213-1.412)
p-value: p=< 0.001
The atherogenic index of plasma is an independent predictor of adverse cardiovascular events in prediabetic patients with unstable angina pectoris, significantly improving risk stratification beyond baseline models.
AIP may refine risk stratification in prediabetic unstable angina; leaves open whether targeting it improves outcomes in trials.
BACKGROUND: The atherogenic index of plasma (AIP) is a novel biomarker associated with atherosclerosis, and an important risk factor for atherosclerosis, but its relation with cardiovascular prognosis in prediabetic patients with unstable angina pectoris (UAP) is still uncertain. METHODS: This study included 1096 prediabetic patients with UAP who were subjected to follow-up for a maximum of 30 months, with cardiac death, refractory angina, and non-fatal myocardial infarction (MI) being the primary cardiovascular endpoints. RESULTS: A significantly increased AIP was observed for the group with primary cardiovascular endpoints. Kaplan-Meier curves corresponding to these endpoints revealed pronounced differences between these two AIP groups (Log-rank P < 0.001). Multivariate Cox proportional hazards analyses highlighted AIP as being independent related to this primary endpoint (HR 1.308, 95% CI: 1.213-1.412, P < 0.001). AIP addition to the baseline risk model improved the prediction of the primary endpoint (AUC: baseline model, 0.622, vs. baseline model + AIP, 0.739, P < 0.001). CONCLUSIONS: AIP could be used to predict cardiovascular events in prediabetic individuals with UAP.
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Liu et al. (2023) conducted a cohort in Prediabetes with unstable angina pectoris (n=1,096). Atherogenic index of plasma (AIP) vs. Baseline risk model was evaluated on Composite of cardiac death, refractory angina, and non-fatal myocardial infarction (HR 1.308, 95% CI 1.213-1.412, p=< 0.001). Each unit increase in the atherogenic index of plasma independently predicted an increased risk of cardiovascular events (HR 1.308) in prediabetic patients with unstable angina pectoris.
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