Why the study?
Does sympathetic dominance during stress differ between patients with Major Depressive Disorder and control subjects?
Does sympathetic dominance during stress differ between patients with Major Depressive Disorder and control subjects?
Autonomic nervous system reactivity to a stressor, measured via HRV, is lower in MDD patients and may serve as a biomarker for early diagnosis and monitoring.
the power at the frequencies where TFC between HRV and respiration is significant, whereas sympathetic dominance is measured as the normalized power in the low frequency band [0.04, 0.15] Hz of HRV excluding the power of those frequencies related to respiration. Results showed significantly lower (p < 0.05) sympathetic dominance in MDD with respect to CT subjects during stress, suggesting that ANS reactivity as response to stress stimuli is lower in MDD patients. The study of ANS reactivity to a stressor may serve as a biomarker useful for the early diagnosis and monitoring of MDD patients.
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Kontaxis et al. (2018) studied this question.
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