A new noncontact multielectrode array catheter accurately located driven electrodes to within 2.33±0.44 mm and correlated with contact electrograms at 0.966 in canine models.
Does a new noncontact multielectrode array catheter accurately map the left ventricular endocardium compared to standard contact mapping in preclinical models?
A novel noncontact multielectrode array catheter system accurately maps the left ventricular endocardium during a single cardiac cycle in preclinical models.
BACKGROUND: Improvements in cardiac mapping are required to advance our understanding and treatment of arrhythmias. This study validated a new noncontact multielectrode array catheter and accompanying analysis system to provide electroanatomic mapping of the entire left ventricular (LV) endocardium during a single beat. METHODS AND RESULTS: A 9F 64-electrode balloon array catheter with an inflated size of 1.8x4.6 cm was used to simultaneously record electrical potentials generated by the heart and locate a standard electrophysiology (EP) catheter within the same chamber. By use of the recorded location of the EP-catheter tip, LV geometry was determined. Array potentials served as inputs to a high-order boundary-element method to produce 3360 potential points on the endocardial surface translatable into electrograms or color-coded activation maps. Three methods of validation were used: (1) driven electrodes in an in vitro tank were located; (2) waveforms generated from the array catheter were compared with catheter contact waveforms in canine LV; and (3) sites of local LV endocardial activation were located and marked with radiofrequency lesions. Tank testing located a driven electrode to within 2.33+/-0.44 mm. Correlation of timing and morphology of computed versus contact electrograms was 0.966. Radiofrequency lesions marked 17 endocardial pacing sites to within 4.0+/-3.2 mm. CONCLUSIONS: This new system provides anatomically accurate endocardial isopotential mapping during a single cardiac cycle. The locator component enabled placement of a separate EP catheter to any site within the mapped chamber.
Gornick et al. (1999) studied Arrhythmias. Noncontact multielectrode array catheter and analysis system vs. Catheter contact waveforms and driven electrodes was evaluated on Accuracy of locating driven electrodes, correlation of waveforms, and accuracy of locating endocardial pacing sites. A new noncontact multielectrode array catheter accurately located driven electrodes to within 2.33±0.44 mm and correlated with contact electrograms at 0.966 in canine models.
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