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October 31, 1981BMJOpen Access

Cumulative mortality was similar in the observed and treated groups and in the normotensive group.

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Why the study?

Does methyldopa reduce cumulative mortality in elderly residents with diastolic blood pressure ≥100 mm Hg?

Population

n=123 elderly residents of local authority welfare homes in Nottinghamshire with standing or lying diastolic…

Comparison

Methyldopa vs Simple observation

Design

RCT, Randomly allocated

Authors

MSMargaret SpracklingJMJ.R.A. MitchellASA H Short

Discussion

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Overview

Methyldopa confers no mortality benefit in elderly moderate hypertension; challenges presumed survival gains from treating isolated diastolic elevation.

Structured PICO

Does methyldopa reduce cumulative mortality in elderly residents with diastolic blood pressure ≥100 mm Hg?

P
Population
n=123 elderly residents of local authority welfare homes in Nottinghamshire with standing or lying diastolic blood pressure of 100 mm Hg or more (screened from 549 residents).
I
Intervention
Methyldopa
C
Comparator
Simple observation
O
Outcome
Cumulative mortalityhard clinical

Treatment of moderate hypertension with methyldopa did not significantly alter cumulative mortality in this elderly population.

Cite This Study

Sprackling et al. (1981) studied this question.

synapsesocial.com/papers/6a0fa3f42badbc352afe784dhttps://doi.org/10.1136/bmj.283.6300.1151
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