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June 6, 2010Journal of Lipid ResearchOpen Access

High-dose atorvastatin causes a rapid sustained increase in human serum PCSK9 and disrupts its correlation with LDL cholesterol

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Authors

GWGreg WelderUniversity of FloridaIZIssam ZinehUnited States Food and Drug AdministrationMPMichael PacanowskiUnited States Food and Drug Administration

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Welder et al. (2010) studied this question.

synapsesocial.com/papers/6a0fa6d4fa36b6e053fcd157https://doi.org/10.1194/jlr.m008144
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A new method for measurement of total plasma PCSK9: clinical applications2009 · 226 citations
  2. 2Antibody-mediated disruption of the interaction between PCSK9 and the low-density lipoprotein receptor2009 · 101 citations
  3. 3The unique role of proprotein convertase subtilisin/kexin 9 in cholesterol homeostasis2009 · 120 citations
  4. 4Antagonism of Secreted PCSK9 Increases Low Density Lipoprotein Receptor Expression in HepG2 Cells2009 · 155 citations
  5. 5Secreted PCSK9 promotes LDL receptor degradation independently of proteolytic activity2007 · 150 citations