Key result
Catecholamines and divalent cations restored propagated action potentials to guinea pig atrial muscle fibers depolarized by elevated potassium, likely by increasing membrane conductance to calcium.
Population
Guinea pig atrial muscle fibers depolarized and rendered inexcitable by elevation of [K+]o to 22 mM
Design
Preclinical
Authors
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Offers no immediate clinical implications; leaves open mechanistic translation from guinea pig atrial models to human arrhythmias.
Catecholamines restore excitability in potassium-depolarized guinea pig atrial fibers by increasing membrane conductance to calcium.
Achilles J. Pappano (1970) studied Depolarized atrial muscle fibers. Catecholamines (isoproterenol, epinephrine, norepinephrine) and divalent cations was evaluated on Restoration of propagated action potentials and contractions. Catecholamines and divalent cations restored propagated action potentials to guinea pig atrial muscle fibers depolarized by elevated potassium, likely by increasing membrane conductance to calcium.
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