Key result
Factor V Leiden links to higher DVT prevalence versus isolated PE without driving fatal PE.
Does not support FVL testing for fatal PE risk in severe illness; leaves open utility for DVT-predominant VTE stratification.
Venous thromboembolism (VTE) is the third most common cardiovascular disease which is an under-appreciated contributor to the global burden of non-communicable diseases. Previously pulmonary embolism (PE) and deep vein thrombosis (DVT) were regarded as a single disease entity and still today, public awareness of DVT and PE remains comparatively low. But after recognition of genetic factors, such as Factor V Leiden (FVL), the concept has been changing. More studies are going on to observe the correlation between the genetic factors, such as FVL and PE.
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Mukesh et al. (2018) conducted a review in Pulmonary Embolism and Deep Vein Thrombosis. Factor V Leiden was evaluated. Factor V Leiden is associated with a higher prevalence of deep vein thrombosis compared to isolated pulmonary embolism, and plays no additional role in fatal pulmonary emboli in patients with severe illness.
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