What question did this study set out to answer?

To compare the safety of continuous versus intermittent heparin therapy in patients needing anticoagulation.

September 20, 1976JAMA

Randomized prospective trial of continuous vs intermittent heparin therapy

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Randomized trial finds continuous heparin therapy safer than intermittent in patients, suggesting better hemorrhagic control.

To compare the safety of continuous versus intermittent heparin therapy in patients needing anticoagulation.
Randomized trial involving 41 patients requiring heparin therapy.
Participants received either continuous intravenous heparin sodium or intermittent heparin therapy with control by activated partial thromboplastin time.
Outcomes assessed included major bleeding episodes and thromboembolism occurrences.
7 of 21 patients on intermittent therapy experienced major bleeding, while none on continuous therapy (P=0.005).
1 patient on continuous therapy developed a pulmonary embolus, while none on intermittent therapy had recurrent thromboembolism.
2 heavily bleeding patients from the intermittent group were switched to continuous therapy after their bleeding was controlled.

R. L. Glazier (1976) studied this question.

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