Regulation of granulopoiesis: lessons from leukocyte adhesion deficiency

The mechanisms that regulate granulopoiesis, in particular, stress (or “emergency”) granulopoiesis, are incompletely understood. Studies of granulocyte colony-stimulating factor (G-CSF) or G-CSF receptor–deficient mice provide strong evidence that G-CSF is the principal hematopoietic cytokine