Key result
Elevated birth LDL-C, non-HDL-C, and Lp(a) predict persistently higher lipid levels through 16 months.
Why the study?
Lipid parameters during the first 14-16 months of life and their influential factors were not well characterized, including whether high concentrations at birth predict later levels.
Cohort (n=13,354)
Atherogenic lipid traits increase stepwise during the first 14-16 months of life, and high levels at birth predict higher levels later, which may inform the optimal timing for universal familial hypercholesterolemia screening in children.
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Birth lipid tracking to 16 months may inform FH screening timing; leaves open prospective validation before any practice change.
Nielsen et al. (2023) reported a cohort. Lipid concentrations above the 80th percentile at birth vs. Lipid concentrations at or below the 80th percentile at birth was evaluated on Lipid concentrations at 2 and 14-16 months. Infants with LDL cholesterol, non-HDL cholesterol, and lipoprotein(a) concentrations above the 80th percentile at birth had significantly higher concentrations at 2 and 14-16 months.