Why the study?
Thyroid laboratory evaluation is often performed routinely in complete heart block despite limited supporting data, prompting evaluation of thyroid dysfunction frequency in patients without clinical hypothyroidism features.
Does routine measurement of TSH identify thyroid dysfunction in patients presenting with third-degree AV block without clinical features of hypothyroidism?
Does routine measurement of TSH identify thyroid dysfunction in patients presenting with third-degree AV block without clinical features of hypothyroidism?
Routine TSH screening in clinically euthyroid patients presenting with complete heart block yields a very low rate of abnormal results, suggesting it may be unnecessary.
Very low TSH abnormality rate in euthyroid third-degree AV block; hypothesis-generating and should not yet change practice.
Background Hypothyroidism can be a cause of sinus bradycardia. However, thyroid laboratory evaluation is often performed routinely in patients with complete heart block (CHB) though there is little data to support this practice. This study aimed to assess the frequency of thyroid dysfunction in patients presenting with CHB without clinical features of hypothyroidism. Methodology All patients referred for permanent pacemaker implantation for CHB were included in this cross-sectional study. Patients with known thyroid disorder or clinical features of thyroid disorder were excluded. Demographic, electrocardiography (EKG), and routine thyroid stimulating hormone (TSH) screening results were recorded. Results A total of 102 patients with complete atrioventricular (AV) block were enrolled in the study of which 50.0% (51) were male. The mean age was 61.09 ± 11.74. Co-morbidities included diabetes mellitus 44.1% (45), smoking 36.3% (37), and hypertension 55.9% (57). Mean EKG atrial rate was 82.97 ± 31.31 mmHg with a mean ventricular escape rate of 36.17 ± 5.93. Permanent pacemakers were implanted in all of the patients. Only one patient had an abnormal TSH. Conclusions We found a very low prevalence of thyroid dysfunction among patients without clinical features of thyroid dysfunction presenting with third-degree AV block. This calls for cautious prescription of thyroid testing in clinically euthyroid patients.
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Faisal et al. (2021) studied this question.
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