Vitamin C: A New Look

Editorials15 May 1991Vitamin C: A New LookGladys Block, PhD, Donald Earl Henson, MD, Mark Levine, MDGladys Block, PhD, Donald Earl Henson, MD, Mark Levine, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-10-909 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptResearchers from many disciplines convened on 10 to 12 September 1990 at the National Institutes of Health to discuss vitamin C, its biologic functions, and its relation to cancer. Sponsored by the National Cancer Institute and the National Institute of Diabetes and Digestive and Kidney Diseases, the conference provided a forum for the presentation of data on the biologic and clinical actions of vitamin C. The data caused many participants to reconsider the importance of this agent in physiologic and clinical events.Vitamin C participates in numerous physiologic processes, many of which may have clinical implications. For instance, it is...References1. Dunn W, Rettura G, Seifter E, and Englard S. Carnitine biosynthesis from gamma-butyrobetaine and from exogenous protein-bound 6-N-trimethyl-L-lysine by the perfused guinea pig liver. J Biol Chem. 1984;259:10764-70. CrossrefMedlineGoogle Scholar2. Peterkofsky B and Udenfriend S. Enzymatic hydroxylation of proline in microsomal polypeptide leading to formation of collagen. Proc Natl Acad Sci U S A. 1965;53:335-42. CrossrefMedlineGoogle Scholar3. May V and Eipper B. Regulation of peptide amidation in cultured pituitary cells. J Biol Chem. 1985;260:16224-31. CrossrefMedlineGoogle Scholar4. Dhariwal K, Washko P, Hartzell W, and Levine M. Ascorbic acid within chromaffin granules: in situ kinetics of norepinephrine biosynthesis. 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Author, Article, and Disclosure InformationAuthors: Gladys Block, PhD; Donald Earl Henson, MD; Mark Levine, MDAffiliations: National Institute of Diabetes and Digestive and Kidney Diseases Bethesda, MD 20892 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCellular landscaping of cisplatin resistance in cervical cancerThe impact of supplementation with pomegranate fruit ( Punica granatum L.) juice on selected antioxidant parameters and markers of iron metabolism in rowersEffect of supplementation with chokeberry juice on the inflammatory status and markers of iron metabolism in rowersEffects of Chenopodium album Linne on Gastritis and Gastric Cancer Cell GrowthProtective Effect of Cimicifuga heracleifolia Ethanol Extract and Its Constituents against Gastric InjuryArsenic trioxide enhances the cytotoxic effect of thalidomide in a KG-1a human acute myelogenous leukemia cell lineAntimony-trioxide- and arsenic-trioxide-induced apoptosis in myelogenic and lymphatic cell lines, recruitment of caspases, and loss of mitochondrial membrane potential are enhanced by modulators of the cellular glutathione redox systemThe effect of methyl sulphonyl methane supplementation on biomarkers of oxidative stress in sport horses following jumping exerciseA novel arsenical has antitumor activity toward As2O3-resistant and MRP1/ABCC1-overexpressing cell linesProtective Effects of Vitamin C on Cisplatin-Induced Renal Damage: A Light and Electron Microscopic StudyFitness, Antioxidants, and Moderate Drinking: All to Lower Cardiovascular RiskAntioxidants vitamin C and vitamin E for the prevention and treatment of cancerDietary Fat Type Affects Vitamins C and E and Biomarkers of Oxidative Status in Peripheral and Brain Tissues of Golden Syrian HamstersAscorbic acid enhances arsenic trioxide–induced cytotoxicity in multiple myeloma cellsImplementation intentions and repeated behaviour: augmenting the predictive validity of the theory of planned behaviourCoronary Artery Responses to Physiological Stimuli Are Improved by Deferoxamine but not by l -Arginine in Non–Insulin-Dependent Diabetic Patients With Angiographically Normal Coronary Arteries and No Other Risk FactorsVitamin C Improves Endothelium-Dependent Vasodilation in Patients With Insulin-Dependent Diabetes MellitusThe effect of core-to-wall ratio and Span 80 concentration on the properties of ascorbic acid microcapsulesPharmacokinetic perspectives on megadoses of ascorbic acidDehydroascorbic acid undergoes hydrolysis on solubilization which can be reversed with mercaptoethanolThe role of ascorbate in antioxidant protection of biomembranes: Interaction with vitamin E and coenzyme Q 15 May 1991Volume 114, Issue 10Page: 909-910KeywordsBiologicsRenal diseasesVitamin C ePublished: 1 December 2008 Issue Published: 15 May 1991 PDF downloadLoading ...