Sudden Death and Left Ventricular Involvement in Arrhythmogenic Cardiomyopathy
Why the study?
ACM was originally described as a right ventricular disease but is increasingly recognized as a biventricular entity, prompting evaluation of pathological, genetic, and clinical associations in SCD.
Population
5205 consecutive SCD cases, including 202 diagnosed with ACM postmortem
Design
Retrospective cohort study of consecutive SCD referrals
Authors
Discussion
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Member takes
Implication
Activity restriction warrants consideration in ACM; challenges RV-centric model but observational autopsy data leave practice change open.
Structured PICO
P
Population
202 cases of sudden cardiac death diagnosed with arrhythmogenic cardiomyopathy (out of 5205 consecutive SCD cases referred to a national cardiac pathology center between 1994 and 2018), mean age 35.4±13.2 years, 82% male.
O
Outcome
Pathological, genetic, and clinical associations including left ventricular histopathologic involvement and circumstances of death
Sudden cardiac death from arrhythmogenic cardiomyopathy predominantly affects men during exertion and is characterized by left ventricular involvement in the vast majority of cases, challenging the traditional view of it as an isolated right ventricular disease.
Cite This Study
Miles et al. (2019) studied this question.