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May 22, 2026Frontiers in GeneticsOpen Access

Multi-omics mendelian randomization integrating GWAS and eQTL data revealed potential drug target for irritable bowel syndrome

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Authors

HKHuiwen KeWCWenchao ChenQZQian Zhang

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Overview

Randomized trial identifies genetic targets for IBS treatment, suggesting new drug development opportunities.

Key Points

  • This study aims to find new genetic targets for drug development in irritable bowel syndrome (IBS).
  • Conducted Mendelian randomization analysis using data from 53,400 IBS cases and 433,201 controls.
  • Integrated genome-wide association studies (GWAS) with blood eQTL data for druggable genes.
  • Performed phenome-wide association study (PheWAS) and molecular docking to validate findings.
  • Identified eight genes with causal associations to IBS, with EP300 (OR: 1.128, 95% CI: 1.079-1.180) and P2RY14 (OR: 1.118, 95% CI: 1.067-1.172) as promising targets.
  • PheWAS showed no significant links of EP300 and P2RY14 to other phenotypes.
  • Molecular docking indicated potential binding of compounds like captopril and menadione to EP300.

Cite This Study

Ke et al. (2026) studied this question.

synapsesocial.com/papers/6a0ff2a8d674f7c03778b2bfhttps://doi.org/10.3389/fgene.2026.1798264
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