Retrospective study analyzes miR-155's association with Th17/Treg imbalance in URPL patients, suggesting its potential as a marker for adverse outcomes.
BACKGROUND: Unexplained recurrent pregnancy loss (URPL) is frequently associated with T helper 17 cells/regulatory T cells (Th17/Treg) imbalance, but the association between microRNA (miR)-155 and Th17/Treg imbalance remains unclear. Therefore, this study preliminarily analysed this association in URPL patients. METHODS: 77) and 91 healthy pregnant women. miR-155, Th17 cells, Treg cells, and Th17/Treg-related cytokines were measured, and the association between miR-155 and Th17/Treg balance was evaluated. The discriminatory performance of miR-155 for adverse pregnancy outcomes (APOs) in URPL was explored with receiver operating characteristic (ROC) curves, and APOs-associated factors were analysed with logistic regression. CONCLUSIONS: Serum miR-155 is reduced in URPL patients and is associated with Th17/Treg imbalance. miR-155 may serve as an exploratory marker to aid in distinguishing APOs in URPL patients, however, its value requires external validation through prospective, multicentre studies.
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Chen et al. (2026) studied this question.
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