ABSTRACT Osteoarthritis (OA) is a common joint disease characterized by degenerative lesions of articular cartilage, subchondral osteosclerosis, osteophyte formation, and synovial inflammation. The traditional view is that OA is a degenerative disease, mainly related to mechanical damage to articular cartilage caused by age, obesity, trauma and other factors. However, in recent years, increasingly more studies have shown that immunoinflammatory responses play a crucial role in the occurrence and development of OA. There are a variety of immune cell infiltration in the joint cavity of OA, and numerous inflammatory factors are released, forming a chronic low‐grade inflammatory microenvironment, promoting articular cartilage degradation and synovial inflammation, and ultimately leading to the occurrence and development of OA. This article reviews the latest research progress on immuno‐inflammatory mechanisms such as immune cell infiltration and inflammatory factor release in OA, and discusses potential strategies for targeted immune response therapy for OA, to provide new ideas for the prevention and treatment of OA.
Lei et al. (Tue,) studied this question.
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